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Some are for options not installed on your truck so they are left open.
It might help if we knew the number of wires in the plug, wire colors, and location as it is hard to see where they are.
Did this issue just start or happen over time?
Did you pull codes to see what the computer has to say?
It also looks like the cooling system needs service, rust all over the engine bay for a blown hose?
Could the coolant gotten into the dist. cap, plug wires or other sensors be the cause if your issue?
Dave ----