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It's the same basic motor besides the camshaft, so strip it to the bare longblock and put all external components from the truck on it and bolt it in. The firing order is different so the plugs have to be routed in the HO firing order, and if it's an '88+ motor it has a roller cam so the distributor will need a steel drive gear, if the motor comes with a distributor use that one.
I can't remember the source, but it was a forum on here or other places, and I don't remember if the HO engine was part of the consideration. Anyway, paraphrased..."The Mustang is a light weight vehicle compared to the truck. The Mustang cams are for moving that lightweight vehicle swiftly. The cams in the truck are for providing a fair amount of torque to do stuff trucks do."
So, if you put the HO in the truck and it's sluggish, the cam setup could be the reason.
The 5.0 doesn't make any low rpm torque and the factory HO cam is really just a decent RV grind, so no a 5.0 HO will not make a truck sluggish compared to the original motor, the complete opposite in fact, the truck will perform much better than it ever did.