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I dont tow much and i like the mileage f my dads f150 but like the f250 body better its a regular cab long bed 2wd its about the same weight i was the ng maybe i could get the conversion wirings haness for it but not sure on trans
You need a complete engine, trans, wiring harness and PCM, rad and support, driveshaft, and probably a bunch more little things all from another 2000 F250 of the same wheelbase. The swap is possible but not worth it IMO.
If your 7.3 is getting bad enough mileage for you to consider this swap, you will NOT get any better with a 4.6. The reason for the mileage is the F250 itself, not the engine.