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I have a 2011 SuperCab F150 5.0 with 77,000 on the clock that I use as a second vehicle. No issues with it. I bought it used a few months ago, took it to a mechanic I have known for years, had him do maintence on it, and check it from front to back. He gave it a clean bill of health and said the truck had been maintained well.
I just got rid of a 2012 Supercrew with the 5.0 that I bought new and traded in on my 2016. No issues with that truck either for the entire 4.5 years I owned it. I bought an Ecoboost on my new truck because I wanted to give the Ecoboost a try, but that 5.0 is a damn good motor, and I would have no reservations about buying another one.