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Hello!
I have a 2010 E350 v8 (92k) that misfires at 40 mph. I brought the van in for a tuneup (oil, filter,pcv, plugs) The van ran perfect for 3 weeks and then the misfiring came right back! My mechanic gave me a bottle of fuel injector cleaner but that didn't work either. Engine is saying random misfire. What do I do?
There's a decent chance your catalytic converters are bad. Disconnect them at the engine and look down in the exhaust pipes.
Pretty common problem here, and very similar symptoms