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If the radio harness hasn't already been chopped up, the best bet is to get an adapter plug set from Crutchfield.com. These will plug directly into the factory harness which increased the likelihood of a successful and reliable installation. The wires on the adapter plug get connected to the wires from the stereo.
I'm not sure how accurate this is, but it should get you started. It's something I found doing a "SEARCH"
1989 Ford F250 Truck Stereo Wiring Information Radio Battery Constant 12v+ Wire: Green/Yellow Radio Accessory Switched 12v+ Wire: Yellow/Black Radio Ground Wire: Black Radio Illumination Wire: Blue/Red Left Front Speaker Positive Wire (+): Orange/Green Left Front Speaker Negative Wire (-): Black/White Right Front Speaker Positive Wire (+): White/Green Right Front Speaker Negative Wire (-): Black/White Left Rear Speaker Positive Wire (+): Pink/Green Left Rear Speaker Negative Wire (-): Pink/Blue Right Rear Speaker Positive Wire (+): Pink/Blue Right Rear Speaker Negative Wire (-): Green/Orange
I will agree it is best to use the wiring adapters and not hack the trucks harness...
Rezvani's Latest Post-Apocalytic Monster Is a Ford F-150 Raptor Underneath
Slideshow: Called the Fortress, the 850-horsepower pickup combines Raptor underpinnings with military-inspired features, survival equipment, and a starting price of $285,000.