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Typical tune experience is that the higher performance tunes actually provide better fuel economy IF you can keep your right foot under control. You just need to invest in a SCT Tim.
I don't know of many people using Superchips. Like npcc said, the best mpg gains are usually obtained by driving conservatively with a non conservative tune
i dont know about the super chips but when i got my SCT i gained about 1mpg with it in the street tune. after a couple weeks i called up matt and got his custom SRL tune and gained 2.5 to 3 mpg. so im getting a combined city driving and highway driving 18.8 to 19mpg math done by hand held calculator at every fill up and fill to the rim. i also run power service diesel kleen every tank which helps some too.