I find this very true on my past two F350’s. Sure you could put 37’s on a new designed F350 fender well clearance with a 2 to 4 inch lift but I guarantee if I take it out 4 x 4ing I will make it rub all over the place. I do not like massively lifted trucks with a lot of wheel clearance but if that is what it takes to make it function in real 4 x 4ing then I have to do that.