I was wondering how hard it would be to swap out a 351 for a 460. The truck is a '95 F-250 351 E4OD and the 460 is currently in a '93 F350 460 E4OD. Both truck have E4OD transmissions, but I didn't know what issues I would have with electronics.

 

You'll need to move the complete 460 engine, transmission, computer and engine wiring harness. You may get away with the 351 wiring, but you'll have to check computer pin locations, some wires may need to be re-routed and/or lengthened... may be easier/quicker to just use the 460 harness as indicated.