I went to look at a 460 today, the heads are d3ve-a2a and the block us d1ve-6015-a2. I believe the motor is all factory. What would I need to make 400 to 450 HP with this motor.

 

Welcome to FTE. Not a lot of performance talk here, mostly keep it running and gas mileage from what I see. But, there is a "cook book" here, and it will point you in the general direction of the HP target you have:

460 Horsepower Chart (revised 1/24/09) - 460 Ford Forum

 

What he said. Both are invaluable. I ended up getting a badass 460 (468 to be exact) from asking questions there specific to the 460 I wanted. Scotty the Mad Porter. Definitely among the most knowledgeable and helpful there, and there are many. From here I get the nuts and bolts insights for the rest of the truck.