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Possibly. I do not know if the pivot bushing in the middle is the same size. Of course you know everything out at the wheel will be f150(different brakes, different lug pattern, etc.)
I am not sure about the f350. The f250 2wd beams are the same length as the f150 beams, but I do not know if the original poster realizes he would be basically turning his f250 into a f150, and he would need to change out the rearend, wheels, etc.