If the truck isnt missing, I wouldnt change them....the gactory plugs and wires are good for 100,000miles.
If you do have to change them.....the 4.6 isnt nearly as bad as the 5.4. however, with some patience and a good set of sockets and extensions, you should be able to handel it. Once you loosen the plug, use a peice of tubing to screw the rest of the way out and to lift out of the hole.
there is a very good step by step instruction sheet on this web. Just do a search
Goodluck
Bowdog