Can this be done?
 

Is it possible/feasible to put a '94 460(e4od/E350/38k) into a '97 E350 with a 5.4Triton (e4od/250k)? Will engine harnesses plug right in? Is replacing all the suspension worth the effort? The '94 low mileage motor is in a RV that the leaking roof has destroyed. Everything from the seats forward is practically new. The '97 (extended, bubble top with wheel chair lift on the side) has a quarter million miles on it. Been reading horror stories about the Triton 5.4L. Would love the power and the freshness of the 460. Please advise. Thanks all

Yes.

No not even close. To make this work you would have to transfer all powertrain wiring from the '94 into the '97.

It should be very similar but why would you want to? Are the springs and bushings sacked?

The motor mounts are probably different and I'm clueless if you can swap k-members. I doubt anyone makes adapters but you never know. You will also need the e4od that is behind the 460.

20 hp and 124 lbft more.. idk if your really gonna feel much of a difference. maybe low rpms pulling... but it wont really be any faster.. besides the power increase will probably just offset the weight difference..

Conversion
 

Appreciate all replies. I was hoping to find a wrench turner from the mid-90's who would be familiar with the change over in 1997. They would have insight as to the problems facing such an conversion. I thought that Ford would not want to completely change every engine connection on the body for the new engine. I know the engine harness' would be different, but maybe not the harness' connecting the engine to the firewall and body. I am not all hyped up to try this. It seems such a waste of the 460. It will never see the road again. I thought I might be able to make this work and have all the power I might need as well as have a motor that could outlast me. As far as suspension goes, why not use the low mileage steering linkage on the '94? Anyway, I did not get the replies I had hoped. It has never been about more power, but about a solid, well developed, well proven motor just barely broke in compared to a well worn first year new power train with some new engine issues.

I feel your pain but with '96 being the year vehicles were switched to OBD2 these two powertrain control systems are VERY different so there is literally nothing that would plug and play here. I suggest you look for another '95 or older truck or van that needs a powertrain, drop the 460 in and flip it to make some cash.