Hey guys,
Here’s my story. I have an 03 f250 superduty with a v10 that pushed a rod through both sides of the block at 140k miles. I already have a reman waiting to go back in. I wanted to get more out of that v10, so I purchased an 05 f350 with a 5.4 with a 6 speed tranny which I want to mate to the v10. I believe I have all harness/ gauges, etc. I searched around for a turbo kit or supercharger to bolt in as well. But to no avail. So my thought came to drilling holes into the intake and supplying compressed air whenI desire a neck jerk. Any thoughts?

Todd, your compressed air idea is not going to work for the reasons given above, foreget about that plan.
What rear gears does this 2V V-10 have, and what size tire's? Going to deeper gears is the single biggest performance increase you can do for your 6.8 (that is, short of a well engineered turbo or super charged system, which will not be nearly as cheap as those new deeper gears). Running anything less than an effective 4.30 ratio and expecting very good performance may lead to some disappointment.

I would do some double checking of the parts you have on hand, the internals of the 4R100 auto trans had heavier internal parts for the V-10 over what the 5.4 V-10 had due to the 6.8's higher output, I'm not sure if the manual transmissions were setup the same way, that 5.4 six speed might not be strong enough to last behind the 6.8. Also I'm not sure if the bell housing bolt patterns were the same between the 2V and later 3V modular motors, so you may want to verify if the '05 trans and bell housing will even bolt up to the 2V ten.

I I acquired an 05 f350 superduty with the 5.4 and 6 speed automatic transmission. I was hoping there would be an adapter to mate the 6 speed to the v10. I do realize the 6r is not as beefy as the 4l100 but with some adjustments to the shift settings, I hope to keep the torque within tolerance. I believe this type of setup is in a few f650. But like 2016 and up. So. I thought you kind gentleman had an inside of what my end outcome would entail.

thanks for your input. The truck has stock size tires and rearends.

Stock rearends is fine, but it doesn't tell us what gears they have, THAT is the important part of the puzzle, there were different ratios available when new from .
I misunderstood your original post and thought that you were talking about a six speed manual trans not an auto, the 6R110 is typically referred to as a five speed since that how many of its six gears it uses. They have a different bolt pattern i'm pretty sure. And I think you are in for a very serious challenge getting the combo work correctly.
I would look at some new deeper gears and go that direction..............

Yep, you are correct, my bad! . 5R110W it is then if the donor truck is an '05, I was thinking ZF6 also originally, confusing.......

well that is true in truck form but you could get a v10 e series van which remained 2 valve for the entire e series line with a 5r110w so the question in the back of my mind has always been if there is a way with a van pcm tune and trans wiring harness to make that combo work in a truck, though if the truck is 4x4 you would need a 4x4 trans from a truck or have to take the whole van trans apart to convert it to 4x4 Unless that is only for the 4r100 can’t recall at the moment but I seem to recall it being both transmissions. Just throwing it out there but probably isn’t practical either unless you really wanted the torqueshift and had some cash burning a hole in your pocket and time to experiment, or some one else would have posted about it before me. Thoughts...