Their is probably a thread on here with my answer but I'm on my iPhone and can't search so any help is appreciated it. I've got a 92 f150 5.0 automatic 4x4 with e4od transmission. Just cracked the head. Have a 91 5.8 automatic 2wd with c4 transmission. Will the 351 work in my truck and with my e4od?

 

I hate the iPhone for searching. If you click search, and then click advanced, it won't jump out of the search box on you. It will allow you to type your search in and not go all crazy on you.

But anyway...
The motor has nothing to do with if it will work or not. With a flexplate swap, it will literally all bolt in. Use the wire harness from the original motor, and then get a 351 computer for an e4od and you're done. It will run on the 302 computer but the 351 is better.