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It would be really heavy. Probably would impede shutting doors because it's so thick. I don't know if you would do the inside of the door jams and all but it would be very expensive. Now, probably not more than a good paint job though... Good paint on a F250 ~ guessing 5-10k. Not a Maaco job.
i did the lower half of my truck with rustolum spray on bed liker and it turned out really good-i did my '96 f-150 and it held up extreamly well-even eith my abuse
I have used rustolium bed liner quite a bit as well. It really does look awesome if you use about 10 light coats. Like $6.50 a can too. Also, if area gets scratched, you cab re paint with it. It will blend right in.
I have seen both used, but never on the whole truck, usually just the lower panels. The products are twin brothers from different mothers, but I personally prefer Line-X. I don't think that either is worth the cost (figure $450-500 for just a bedliner) unless you are doing some serious offroading or put in most of your miles on unpaved roads.