When you click on links to various merchants on this site and make a purchase, this can result in this site earning a commission. Affiliate programs and affiliations include, but are not limited to, the eBay Partner Network.
It wouldn't be a bolt up operation as the F250 4x4's had leaf springs up front, but you could convert an F150 4x4 front-end (coil sprung) to F250 by changing the spindles and hubs. They are both Dana 44s.
Actually IIRC the holes are the for everything except the mounting holes for the TTB pivot brackets. And I believe the frame holes are there for the trans/t-case C/M.