Way too many variables in this comparison.

Maintenance?
Rear end gear ratio?
Effective gear ratio (transmission and rear end gear)?
Torque strategy?
Weight (curb and loaded)?
Tire and rim size?
RPMs at crusing speed?

If you want to wake the F250 up, I suugest you contact Mike at 5startuning.com about an SCT programmer with custom tunes.

Personally I wouldn't bother with the warmer-air-than-stock after market intake (unless you are simply looking for under the hood bling) or exhaust (unless you're looking for a meaner sound - which can increase butt dyno sensitivity).