Clifford Performance/Research makes a ton of stuff for Ford 6 cylinders. Everyone that I know that has hopped up a 60s Ford 6 cylinder has used at least some Clifford products. I do not know how much of it will work on an E-100, but they can probably tell you.

Here is a link tho their catalog page for the Ford 300.

Clifford Performance: Ford 300 & 223