Yes you can.

You can do anything.

There are videos of 250's with 466's in them on the net. Search "466 super duty"

Youre' stock tranny might not be a bright idea, the 466 can produce scary amounts of torque, and guys have gotten 2000+ HP out of them for pulling.

You could say a 466 to a cummins is a cummins to a GM 6.5 liter.

Be prepared to get creative though, engine barely fits in truck.