Why on earth would you consider a 2V V-10 and worry about fuel mileage?
Super Duty trucks don't get great fuel mileage. They are heavy and not very aerodynamic. My best was 18 MPG (3V 5.4L, 3.73 gears, flat roads and a stiff tail wind). Purchasing a Super Duty and worrying about the fuel mileage is like buying a home next to an airport and worrying about the noise.