I've been battling with this decision myself for a while. I did a lot of research and even bought a conversion kit. I was going to do the conversion about a month ago, but just could'nt bring myself to do it. The old 2bbl carb was simple and nearly trouble free for 30 years and almost 300K miles, so I just swapped it for a 4bbl a buddy gave my off his Mustang. I have a roller cam 5.0 in the corner of the garage I'll swap in when this motor goes, so I might wait install it then.
Here's a few links to make you decision just a little more difficult
https://www.ford-trucks.com/article/...250_Truck.html
http://www.mass-floefi.com/
http://www.retrotekspeed.com/product...ion-i-systems/
http://www.edelbrock.com/automotive_...pf_intro.shtml
http://www.affordable-fuel-injection...on=show_detail