archangel
I have a 4160 Holley, 600 CFM and a 1411 Edelbrock, 750 CFM that I run on my 460.
They both will run about 11 mpg all the time with combined city and highway driving. The Edelbrock has gotten the best of the 2 on straight highway driving @ a smidge over 13 mpg.
The 2166 is a non- EGR, Performer intake.
I assume your truck is a two wheel drive? If so, and your gears are not too steep. you may do a little better.
But hey, it is a big motor.