A month or so ago there was a Mustang for sale on Ebay....it had a V-10 under the hood. I asked myself....WHY....then answered myself.....because he could. It would be a very unique motor to go in a hot rod, but would have very limited off the shelf resources to pull from for power or dress up. But then, I say go for it and keep us informed on the project as it moves forward. There is a lot of great tech information you can pull from others here.
Of course I am one of those persons who thinks it is just wrong to build a Hot Rod from a Model A or T or Cobra kit car and put a Chevy powertrain under it......it just ain't right.