Orange Juice,
I built a 545 for my 79 F350. Used a Scat kit of a 4.5 stroker crank, 6.7 H rods and dished forged aluminum pistons. This combo gives 10.5 to 1 compression ratio with aluminum John Kasse Super Cobra Jet heads. I used a mild Comp Cam Extreme Energy cam, hydraulic lifters and roller rockers. I topped it off with an Edelbrock RPM Air Gap intake & a Holley 750 double pumper. It dyno'd at 500 HP at 4500 RPM and over 600 ftlbs torque from 2000 to 4500 RMM.
With the way I set this up, if I decide I want more HP, etc - basically all I have to do is change the cam and or add nitrous.
I've had this for over a year and so far no problems or complaints.