I very seldom disagree with anyone in here, Scott, but I gotta take a shot at just one of your statements: The random misfire of a COP.

If a COP spikes high or low it will not give the plug the proper power to fire. This usually happens under load. I don't understand the High-Side power failure, but the Low-Side failure goes without saying.

A COP on the verge of failure has casued many a good tech to take a nip now and then. Sometimes it takes dedication on the part of the tech, while he's in-cabin, going down the road with a load on the truck.

But - after all that typing - it could be an injector or its connector; a COP or its connector; or a boot that was manufactured with a flaw.
I just can't see bad fuel being the culprit.