I run bio in my 6L and it runs great on B100, the engine sounds very smooth, and the truck doesn't seem to loose any power. During the winter I was up in the mountains and it got down to 32 degrees at night and didn't not have any problems starting in the morning. I have had some injector problems recently though with my truck. I don't think it was related to the bio but the fact that my fuel filters got so clogged that the injectors starved for fuel. Another reason I don't think the bio was to blame is because my OASIS report states that 4 injectors were replaced 15k miles ago and im guessing the previous owner was using regular deisel. I would say that if you decide to use bio make sure you at least check your fuel filters and change them if necissary.