it depends on how disassembled you mean?

i driven without anything in the interiour before, just a seat and dash structor with a tac still working when i was redoing my mach 1.

i think while all the safety devices are in place, it should be no problem.

i think i heard somewhere in some places its illegal to drive without a bed on a truck, i don't see why if you have lights installed, but thats just what i heard. and same with a hood also.