I have a 2004 6.0.
have run every ratio from a B2 blend up to straight B100 from a pump and homemade.
never has an issue but i do change fuel filters @ every 10K miles as opposed to the usual 15K limit.
Runs quiter with more bio.
Power feels the same.

Am gonna make my own soon. My goal is to make a super high cetane formula at home.