Best made for what?
You ask a question, that has too many possible answers.
Are they reliable, yes as much as any motor. They have their problems.
Do they get good milage, not any better than a small V-8.
My preference for favorite six, would a Jeep 4.0l. Smaller,lighter, better mileage, good power numbers for a straight six, outstanding reliabilty. Compared to the Ford 300.