We have one of each. My F250 V10 and my wife's new F150 Crew 5.4L.

The F150 is a much more comfortable & quiet ride. The F250 is a work truck with much heavier components and you can tell it by the way it rides and handles. I have no complaints with either one-they're both what I expected.

The V10 feels more powerful taking off from a dead stop and it will out-accelerate the F150 0-60 and make it real close for a 1/4 mile. However, the 5.4L in our F150 seems to do better accelerating at speed once it's up to highway speeds. If you need to pass a car quick in the interstate the F150 has the advantage. Makes senese to me-the V10 in my F250 has more torque at 1700rpm than the 5.4L makes at it's peak.

Of course towing the V10 will have the advantage hands down. I tow my enclosed trailer at 6500lbs and it stays in OD or 3rd 90% of the time, even on hills.

Mileage. My F250 averages 11/12 mixed driving and a little over 14hwy, The F150 is still new and is averaging 13/14 mixed driving and a little over 15hwy. In my case there's not much difference. Honestly we're a little disappointed in the F150's mpg. Hope it gets better. The V10 is hauling around an extra 1400lbs of curb weight and only gets about 1mpg worse than the 5.4L.