Hey all..long time no see..

I found a truck in Seattle WA that I want and am considering flying there and driving it home. It is a 1977 F250 extended cab long bed. Everything under the hood is new, including a fresh 460 (800miles on it..I have photos and receipts of work done)...alt, starter, carb, intake, heater core, 2 batteries, newer tires, late 90-s ford alum rims, gear vender overdrive...no rust, straight, solid..sweet old truck. Anyway, considering the elevation changes that I will encounter on the way back, what precautions should I take? what shoudl I expect, if anything....? I was worried, with the motor being new...if the tuning was off a bit I might get some ping if it leans out... help!
Thanks
Mike