Don't drill..
I used the bed ties when I was toting my old mitchell 8footer.
Worked fine but...
I installed tork-lifts when I bought my new 8footer.
Nice to know it's tied to a sturdy foundation.

Seems Ford updated my bed with some 00 cable running through the bed supports and tied to the frame. Ford did this on my tank recall.
Did Ford have some issue with campers twisting the bed off of the frame?. Hmmmm. They only did it to the camper specials.
With that in mind I changed to the tork-lifts.
I didn't consider happi-jacs

99.5 Ford Super Duty F-250 XLT 4x4. S/C L.W.B. PSD Auto loaded.
4 in. Pro-Comp lift. 35 x 12.5 x 16.5 BFG AT/KO. Weld SSII 16.5 x 9.75. Rancho 9000's Dual Front.
Warn M12000 in Semi-hidden mount. Astro-start Supreme 3006.