My wife's got the HD 4R100 in her truck. It was there when we bought it. Shifting was awful with the Edge tuner it came with. We put in a Transgo tugger kit and tunes from Total Diesel Performance. She doesn't have any problems with hard lock up or anything of that nature. We told Tony about the tranny and tugger kit, so maybe he did some adjusting, or maybe not.
I've heard many tuners up the line pressure to try to firm up the shifts. Maybe that plays into the lock up issues you're having.