IMHO the next big jump in MPG will not be the engine technology alone. There is only so much energy in a gallon of 85 octane fuel. And it takes a quantifiable amount of energy to move a 2-1/2 ton mass. Lighten the vehicle and you will see improvements.
But, what if we could get all of the crankshaft hp to the wheel?
Just sayin'.
EDIT: And Ed - you are absolutely correct about mutliple 'tunes'. Clearly the technology exists. I've yet to figure out why Ford hasn't already implemented it.