How to change Fuel Filter
 

What all is involved in changing out the Fuel Filter on an 07 Expy? Any tips/advice would be greatly appreciated...

Get the proper tool for releasing the clips on the lines. Less than $10.
Put the vehicle on ramps or a lift if you have access to one.
Put on eye protection!!!
Release the line clip and slip out the filter.
Snap in the new filter.

Undo your fuel filler cap too. That will allow any leftover pressure to be released so that you don't get squirted on when you release the lines.

Thanks for the replies, what is the tool that is needed to release the clips? Where is the fuel filter located under the truck?

The tool looks like this. You can usually find them at any auto parts store for $10-$15.

http://www.fordf150.net/howto/images/fuelpic1.jpg