General consensus on here is the 460 will consume a lot of fuel with 4.10 gears or better and when towing but you're not buying one of the biggest gasoline engines ever produced for fuel milage so that's probably not a big concern. I'd say you want 4.10 gears for sure.
i wouldnt swap your until i tried pulling the trailer or one of similar weight, that said 4.10s do good up to 33" tires with a trailer under 10k lbs, my 3.73s had no problem with close to 10klb trailer when i had 33" tires
One other thing to worry about... with some transmissions the overdrive is actually weaker and towing in OD will lead to early failure. I know for a fact the ZF is one, but I don't know if the E4OD is or not. I would head over to the tranny/axle/t-case forum here and see if you can get Mark Kovalsky's attention. Ask him if there is a problem towing in overdrive with an E4OD.