Get the 3.73s. Overall it won't hurt your economy. If it hurts you on the highway, it will help in the city. Also get the limited slip.
Every review I've read has either said that the 5.4 seems "taxed" (Motor Trend) in normal driving or just hasn't mentioned
engine power. So I'd give it all the help you can with the 3.73s. All the shootouts against the other brands also used 3.73s.
So far I've had 2 F150s with 3.55s and I'll never have that ratio again. I find it barely adequate empty on my 2000 and the 09 5.4 only has 15 more ft/lbs and is heavier.
Mike