The truck needs larger injectors and a tune for it. Methanol's a/f ratio is even richer than ethanol and it needs about 50% more fuel. It'll run like a scalded dog properly set up but the mileage will suck.
If its not tuned for it will runway too lean.... boom!
This is a pro-methanol site obviously, and there is enough in their "Use of Methanol as a Transportation Fuel" report of 11/07 to waive off most folks.
(from the main page, click on "Alternative Fuel", then look for the above title)
Research E85 and its octane and availability instead....