You are better off staying with the multi-point injection that the 4.9 aleady has if your truck is new enough to have it. The holley tbi will not work on the 300. It's not configured for this engine.
Itll work...inliners have been doing it for years...
stock 4.9 efi would be the easiest approach, although its still batch fire, and whether its a dramatic improvement over a short runner with TBI, I would imagine is debatable.
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