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If you will note, the axle is slightly wider on a F450 than the F250, F350. There are fender flares as stated above to compensate on the front axle only for this wider, heavier front axle. It looks good, I would like to find out who makes them so I could put them on my SRW F350.
The fenders are definitely different. The cut out for the headlights are new and the fender vents are recessed, the emblem looks like it sits inside.....