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It could be a leak. It could also be a cross-fill problem. There was a recall for certain years because the overflow from the pressure regulator would always return to one tank instead of the tank the gas came from.
My rear tank leaks so I only use the front tank now. As was mentioned, there was a recall on the dual fuel tank Fords. Something about a bad check valve causing fuel from one tank being returned to the other causing a possible overfill with fuel spewing out of the gas cap( I've seen that ).
I have the same problem too, just learned to live with it. I run the front tank to 1/4 and switch to the rear and watch it drop. Within about 120 miles it's bone dry and the front tank is at about 3/4 to 7/8 full. The real problem lies within the check valve in the front sender on my truck, which should be closed when the front pump is not running, but I haven't gotten arround to feeling like paying all that money to fix it. The sender units are not cheap.