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Your heater won't work as good. Your 'check engine light' might turn on for a system too rich code among others. The computer might even figure it out. I don't really think it would hurt your catalyst enough but it might. Your auto transmission may not upshift normally. It probably won't pass a smog test. Your engine may not reach it's operating temperature in cold environments. That's about all I can think of.
Yes it will. Lots of reasons stated above, your engine is designed to run at a certain temperature. Running it cooler than that will cause damage in the long-term, as well as cost you quite a bit of fuel economy.